|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||35197 Da|
|Other Names||RNA-binding protein Musashi homolog 2, Musashi-2, MSI2|
|Target/Specificity||A synthetic peptide corresponding to N-terminus of human Musashi2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Musashi2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).|
|Cellular Location||Cytoplasm. Note=Associated with polysomes.|
|Tissue Location||Ubiquitous; detected at low levels.|
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Provided below are standard protocols that you may find useful for product applications.
Musashi2 (Msi2) is a member of Musashi family of evolutionarily conserved RNA-binding proteins. In mammals, Musashi1 and 2 shares similar primary structure, RNA binding specificity, and expression profile during CNS development. Highly co-expressed with Musashi1 in neural precursor cells, Musashi2 has been linked to proliferation and maintenance of stem cells in central nervous system. With two conserved tandem RNA recognition motifs, Musashi2 binds to target mRNAs and regulates RNA expression at translation level (1). Chromosomal aberrations involving Musashi2 might play a role in disease progression for chronic myeloid leukemia (2).
1. Sakakibara S, et al. The Journal of Neuroscience, 21(20):8091-8107, 2001.
2. Barbouti A, et al, Cancer Research 63:1202-1206, 2003.
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