- CITATIONS: 1
|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||17184 Da|
|Other Names||Myoglobin, MB|
|Target/Specificity||A synthetic peptide corresponding to residues on the C-terminus of human myglobin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Myoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.|
Provided below are standard protocols that you may find useful for product applications.
Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand (1). Myoglobin may serve a variety of functions in muscular oxygen supply, such as oxygen storage, facilitated O(2) diffusion, and myoglobin-mediated oxidative phosphorylation. Disruption of myoglobin results in the activation of multiple compensatory mechanisms that steepen the pO(2) gradient and reduce the diffusion path length for O(2) between capillary and the mitochondria (2).
1. Garry DJ, et al. Nature, 396(6705):905-8, 1998
2. Godecke A, et al. Proc Natl Acad Sci,(18):10495-500, 1999
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.