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Myosin RLC Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - Myosin RLC Antibody (N-term) AJ1522b
    A. Western blot analysis on 293T cell lysate using anti-Myosin RLC RabMAb (Cat. #AJ1522b), dilution 1:1000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19105
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1456Y
Calculated MW 19794 Da
Gene ID 10627
Other Names Myosin regulatory light chain 12A, Epididymis secretory protein Li 24, HEL-S-24, MLC-2B, Myosin RLC, Myosin regulatory light chain 2, nonsarcomeric, Myosin regulatory light chain MRLC3, MYL12A, MLCB, MRLC3, RLC
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Myosin RLC was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMyosin RLC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYL12A
Synonyms MLCB, MRLC3, RLC
Function Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
Research Areas
Citations (0)

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The muscle myosins and hexomeric proteins consisting of two heavy chains and two pairs of light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize the long alpha helical neck of the myosin head (1). Human myosin light chain-2 (MYL2) is an important protein involved in the regulation of myosin ATPase activity in smooth muscle. In cardiac muscle, the precise role of MYL2 is not well understood; however, an increase in ventricular MYL2 is observed during myocardial hypertrophy in cardiac patients with valve stenosis (2). Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease caused by mutations in all of the major sarcomeric proteins, including the ventricular myosin regulatory light-chain (RLC). The Myosin RLC mutation has been associated with a rare variant of cardiac hypertrophy defined by mid-left ventricular obstruction due to papillary muscle hypertrophy. This mutation was later found to cause ventricular and septal hypertrophy (3).


1. Poetter K, et al. Nat Genet 13(1):63-9, 1996
2. Macera MJ, et al. Genomics 13(3):829-31, 1992
3. Szczesna-Cordry D, et al. J Cell Sci 118(16):3675-83, 2005

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Cat# AJ1522b
(40 western blots)
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