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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Na+/K+ ATPase Antibody   

Na+/K+ ATPase Antibody

Rabbit Monoclonal Antibody

  • WB - Na+/K+ ATPase Antibody AJ1524a
    A. Western blot analysis on HeLa cell lysate using anti-Na+/K+ ATPase alpha RabMAb (Cat. #AJ1524a), dilution 1:20,000.
  • IHC - Na+/K+ ATPase Antibody AJ1524a
    B. Immunohistochemical staining of paraffin-embedded human stomach carcinoma using anti- Na+/K+ ATPase alpha RabMAb
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05023
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1845Y
Calculated MW 112896 Da
Gene ID 476
Other Names Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, ATP1A1
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Na+/K+ ATPase α was used as an immungen.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNa+/K+ ATPase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP1A1
Function This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Cellular Location Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations ( 0 )


Na+, K+-ATPase is a heterodimeric enzyme responsible for the active maintenance of sodium and potassium gradients across the plasma membrane (1). The sodium- and potassium-dependent adenosine triphosphatase (Na+,K(+)-ATPase) maintains the transmembrane Na+ gradient to which is coupled all active cellular transport systems (2). It is well accepted that inhibition of the Na,K-ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentration and strengthens cardiac contraction. Assessing the phenotypes of mouse hearts with genetically reduced levels of Na,K-ATPase alpha 1 or alpha 2 isoforms clearly demonstrates different functional roles for these isoforms in vivo. Results definitively illustrate a specific role for the alpha 2 Na,K-ATPase isoform in Ca2+ signaling during cardiac contraction (3).


1. Yang-Feng TL, et al. Genomics 2(2):128-38, 1988
2. Herrera VL, et al. Science 249(4972):1023-6, 1990
3. James PF, et al. Mol Cell 3(5):555-63, 1999.

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Cat# AJ1524a
(40 western blots)
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