- CITATIONS: 5
|Reactivity||Human, Mouse, Rat|
|Calculated MW||99809 Da|
|Other Names||Cadherin-2, CDw325, Neural cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD|
|Target/Specificity||A synthetic peptide corresponding to residues in the extracellular region of human N-Cadherin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||N-Cadherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
Provided below are standard protocols that you may find useful for product applications.
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, R-, B-, and E- cadherins, and other members (1). Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. Findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts (2). Retinoblastoma cells, in contrast with normal retina, express an N-cadherin (cadherin-2)/catenin complex that is irregularly distributed and weakly linked to the cytoskeleton. In retinoblastoma, this complex acts as an invasion promoter (3).
1. Wallis J, et al. Genomics 22(1):172-9, 1994
2. Togashi H, et al. Neuron 35(1):77-89, 2002
3. Van Aken EH, et al. Invest Ophthalmol Vis Sci 43(3): 595-602.
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