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N-Cadherin Antibody

Rabbit Monoclonal Antibody

  • WB - N-Cadherin Antibody AJ1526a
    A. Western blot analysis on (A) Huvec (B) C6 and (C) HeLa cell lysates using anti-N-Cadherin RabMAb (Cat. #AJ1526a), dilution 1:20,000 (A and B); 1:5000 (C).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19022
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR1791-4
Calculated MW 99809 Da
Gene ID 1000
Other Names Cadherin-2, CDw325, Neural cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD
Target/Specificity A synthetic peptide corresponding to residues in the extracellular region of human N-Cadherin was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsN-Cadherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDH2
Synonyms CDHN, NCAD
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P15116}; Single-pass type I membrane protein. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes {ECO:0000250|UniProtKB:P15116}
Research Areas
Citations ( 0 )


The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, R-, B-, and E- cadherins, and other members (1). Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. Findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts (2). Retinoblastoma cells, in contrast with normal retina, express an N-cadherin (cadherin-2)/catenin complex that is irregularly distributed and weakly linked to the cytoskeleton. In retinoblastoma, this complex acts as an invasion promoter (3).


1. Wallis J, et al. Genomics 22(1):172-9, 1994
2. Togashi H, et al. Neuron 35(1):77-89, 2002
3. Van Aken EH, et al. Invest Ophthalmol Vis Sci 43(3): 595-602.

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Cat# AJ1526a
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