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Neuropilin-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Neuropilin-1 Antibody AJ1534a
    A. Western blot analysis on (A) Hu-placenta (B) HUVEC (C) HepG2 cell lysates (D) mouse heart tissue (E) mouse kidney tissue (F) rat heart and (G) rat kidney tissue lysate using anti-Neuropilin-1 RabMAb (Cat. #AJ1534a), dilution 1:1000
  • IHC - Neuropilin-1 Antibody AJ1534a
    B. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Neuropilin 1 RabMAb (Cat. #AJ1534a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14786
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3113
Calculated MW 103134 Da
Gene ID 8829
Other Names Neuropilin-1, Vascular endothelial cell growth factor 165 receptor, CD304, NRP1, NRP, VEGF165R
Target/Specificity A synthetic peptide corresponding to residues in the cytoplasmic region of human Neuropilin-1 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNeuropilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NRP1
Synonyms NRP, VEGF165R
Function The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules
Research Areas
Citations (0)

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Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neurophilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. NP-1 isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis and in the formation of certain neuronal circuits and in organogenesis outside the nervous system (1). The soluble NP-1 isoform 2 binds VEGF(165) and appears to inhibit its binding to cells (2). It may also induce apoptosis by sequestering VEGF(165). NP-1 may bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity (3).


1. Gluzman-Poltorak Z, et al. J Biol Chem 275(24) :18040-5, 2000
2. Shintani Y, et al. EMBO 25(13):3045-55, 2006
3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)

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Cat# AJ1534a
(40 western blots)
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