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NF-H Antibody

Rabbit Monoclonal Antibody

  • WB - NF-H Antibody AJ1538a
    A. Western blot analysis on Rat Brain lysate using anti-NF-H RabMAb (Cat. #AJ1538a), dilution 1:2,000.
  • IHC - NF-H Antibody AJ1538a
    B. Immunohistochemical analysis of paraffin embedded human brain glyoma using anti-NF-H RabMAb (Cat. #AJ1538a).
  • IF - NF-H Antibody AJ1538a
    C. Immunofluorescent staining of PC-12 cells using anti-NF-H RabMAb (Cat. #AJ1538a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12036
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP673Y
Calculated MW 112479 Da
Gene ID 4744
Other Names Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH
Target/Specificity A synthetic peptide corresponding to residues in human NF-H was used as immunogen.
Dilution WB~~1:500~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNF-H Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0845, NFH
Function Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
Research Areas
Citations (0)

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Neurofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Phosphorylation of the NF-H tail domain modulates neurofilament transport, dynamics and organization within the axon. Accumulation of the protein or mutations in NF-H is observed during the progression of numerous neurological diseases such as amyotrophic lateral sclerosis (3).


1. Nixon, R. A., and Shea, T. B. (1992) Cell Motil. Cytoskeleton 22, 81-91
2. Julien, J. P., Meyer, D., Flavell, D., Hurst, J., and Grosveld, F. (1986) Brain Res. 387, 243-250
3. Al-Chalabi et al. Hum. Molec. Genet. 8: 157-164, 1999.

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Cat# AJ1538a
(40 western blots)
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