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>   home   >   Products   >   Primary Antibodies   >   Nm23-H1 Antibody (NDPK-A)   

Nm23-H1 Antibody (NDPK-A)

Rabbit Monoclonal Antibody

  • WB - Nm23-H1 Antibody (NDPK-A) AJ1545a
    A. Western blot analysis on (A) MCF-7, (B) A375, (C) HeLa and (D) Jurkat cell lysates using anti-Nm23-H1 (NDPK-A) RabMAb (Cat. #AJ1545a), dilution 1:5000.
  • IHC - Nm23-H1 Antibody (NDPK-A) AJ1545a
    B. Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using anti-Nm23-H1 RabMAb (Cat. #AJ1545a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15531
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3036
Calculated MW 17149 Da
Gene ID 4830
Other Names Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23
Target/Specificity A synthetic peptide corresponding to residues in human Nm23-H1 (NDPK-A) was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNm23-H1 Antibody (NDPK-A) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NME1
Synonyms NDPKA, NM23
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Cellular Location Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA
Tissue Location Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.
Citations (0)

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NM23-H1 (NDPK-A, NME1) is a nucleoside diphosphate kinase that is responsible for the synthesis of nucleoside triphosphates and is involved in numerous regulatory processes associated with proliferation, development, and differentiation (1). Evidence points to NM23-H1 (NDPK-A) functioning as a metastasis promoter in other human tumors including neuroblastoma (2).


1. Munier A, et al. Exp Cell Res. 289(2):295-306, 2003
2. Almgren M., et al. Molecular Cancer Research 2:387-394, 2004

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Cat# AJ1545a
(40 western blots)
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