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NQO1 Antibody

Rabbit Monoclonal Antibody

  • WB - NQO1 Antibody AJ1554a
    A. Western blot analysis on (A) MCF-7 (B) HeLa and (C) A549 cell lysate using anti-NQO1 RabMAb (Cat. #AJ1554a), dilution 1:50,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15559
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR3309
Calculated MW 30868 Da
Gene ID 1728
Other Names NAD(P)H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1, NQO1, DIA4, NMOR1
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human NQO1 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNQO1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NQO1
Synonyms DIA4, NMOR1
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Cellular Location Cytoplasm.
Research Areas
Citations ( 0 )


NQO1 (Quinone 1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress (1). NQO1 is mainly cytosolic, but its nuclear presence suggests its involvement in both chemoprevention and bioactivation of DNA-damaging antitumor agents (2). NQ01 may also play a role in the bioactivation of antitumor quinones such as mitomycin C (MMC), and has been proposed to have a protective effect against cancer caused by quinones and their metabolic precursors (3-4).


1. Radjendirane V, et al. J Biol Chem. 273(13):7382-9, 1998
2. Winski SL, et al. Cancer Res. 62(5):1420-4, 2002
3. Traver RD, et al. Cancer Res. 52(4):797-802, 1992
4. Jaiswal AK, et al. J Biol Chem. 263(27):13572-8, 1988

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Cat# AJ1554a
(40 western blots)
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