|Calculated MW||51209 Da|
|Other Names||POU domain, class 2, transcription factor 2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding protein 2, Oct-2, Octamer-binding transcription factor 2, OTF-2, POU2F2, OCT2, OTF2|
|Target/Specificity||A synthetic peptide corresponding to residues before the POU domain of human Oct-2 was used as an immunogen. This antibody may detect the isoform 2.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OCT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147|
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Provided below are standard protocols that you may find useful for product applications.
Octamer transcription factor-2 (Oct-2) is a transcription factor that specifically binds to the octamer motif (5- ATTTCAT-3). Mostly expressed in B cells, Oct-2 posses a leucine zipper domain and belongs to the POU family of transcription factors (1-3). Additionally, Oct-2 regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression.
1. Staudt, L. M., Singh, H., Sen, R., Wirth, T., Sharp, P. A. and Baltimore, D. (1986) Nature ( London) 323, 640
2. Scheidereit, C., Heguy, A. and Roeder, R. G. (1987) Cell 51, 783
3. Herr, W. and Cleary, M. A. (1995) Genes Dev. 9, 1679
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