|Application ||WB, IHC|
|Calculated MW||51209 Da|
|Other Names||POU domain, class 2, transcription factor 2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding protein 2, Oct-2, Octamer-binding transcription factor 2, OTF-2, POU2F2, OCT2, OTF2|
|Target/Specificity||A synthetic peptide corresponding to residues in human Oct.-2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OCT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147|
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Provided below are standard protocols that you may find useful for product applications.
Octamer transcription factor-2 (Oct-2) is a transcription factor that specifically binds to the octamer motif (5- ATTTCAT-3). Mostly expressed in B cells, Oct-2 possess a leucine zipper domain and belongs to the POU family of transcription factors (1-3). Additionally, Oct-2 regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression.
1. Staudt, L. M., et al. Nature (London) 323, 640, 1986 2. Scheidereit, C., et al. Cell 51, 783, 1987 3. Herr, W. et al. Genes Dev. 9, 1679, 1995
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