|Application ||WB, IHC|
|Calculated MW||31636 Da|
|Other Names||Homeobox protein OTX2, Orthodenticle homolog 2, OTX2|
|Target/Specificity||A synthetic peptide corresponding to residues in human OTX2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OTX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.|
|Tissue Location||Expressed in brain.|
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Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1); more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).
1. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 2. Chatelain G, et al. J Mol Med. 84(7):604-15, 2006 3. Vernay B, et al. J Neurosci. 25(19):4856-67,2005 4. Henderson RH, et al. Mol Vis. 15:2442-7, 2009 5. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008)
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