|Reactivity||Human, Mouse, Rat|
|Calculated MW||107895 Da|
|Other Names||General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, TAP, Vesicle-docking protein, USO1, VDP|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human p115 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||p115 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.|
|Cellular Location||Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.|
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Provided below are standard protocols that you may find useful for product applications.
p115 / TAP (Vesicle docking protein p115, Transcytosis-associated protein) is a general vesicular transport factor located in the Golgi complex. p115 is part of the Golgin protein family, defined by their location in the Golgi matrix and their long coiled-coil domain. p115 is thought to be essential for ER to Golgi traffic (1). Specifically, p115 is required for intercisternal transportation within the Golgi stack and required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane (2). Also, p115 has been suggested to be act as a vesicular anchor to the target membrane.
1. Alvarez C et al., JBC 276(4):2693-2700, 2001.
2. Shorter J, Warren G et al., JBC 146(1):57-70, 1999.
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