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p120 Catenin Antibody Phospho (pT310)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1563e | 100ul 400 ul | 2-3 days | $ 355.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
p120 Catenin Antibody Phospho (pT310) - Product info | |
| Application | WB, IHC
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| Primary Accession | O60716 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EPR2382 |
| Calculated MW | 108170 Da |
| Gene ID 1500 | |
| Other Names ST13, FAM10A1, HIP, SNC6, Hsc70-interacting protein, Suppression of tumorigenicity protein 13;Putative tumor suppressor ST13;Protein FAM10A1;Progesterone receptor-associated p48 protein;Renal carcinoma antigen NY-REN-33 | |
| Target/Specificity A phospho-specific peptide corresponding to residues in human p120 Catenin was used as an immunogen. The antibody only detect p120 Catenin phosphorylated on Threonine 310. | |
| Dilution WB~~1:500~1000 IHC~~1:100~250 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions p120 Catenin Antibody Phospho (pT310) is for research use only and not for use in diagnostic or therapeutic procedures. | |
p120 Catenin Antibody Phospho (pT310) - Protein Information | |
| Name CTNND1 | |
| Synonyms KIAA0384 | |
| Function Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins Implicated both in cell transformation by SRC and in ligand- induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage | |
| Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm | |
| Tissue Location Expressed in vascular endothelium. | |
p120 Catenin Antibody Phospho (pT310) - Related products
AJ1138a: Catenin (p120) Antibody Phospho (pY228)
AJ1138b: Catenin (p120) Antibody Phospho (pY291)
AJ1563a: p120 (Catenin) Antibody Phospho (pY96)
AJ1563b: p120 Catenin Antibody
AJ1563c: p120 Catenin Antibody
AJ1563d: p120 Catenin Antibody Phospho (pS268)
p120 Catenin Antibody Phospho (pT310) - Application data
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A. Western blot analysis on 293T cell lysates using anti-Phospho-p120 Catenin (pT310) RabMAb (Cat. #AJ1563e), 1:5000 dilution. Cells were either (A) untreated (B) treated with Calyculin A
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B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Phospho-specific anti-p120 Catenin RabMAb (Cat. #AJ1563e).
p120 Catenin Antibody Phospho (pT310) - Research Areas
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BACKGROUND
Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
REFERENCES
1. Keirsebilck, A., et al. Genomics 50: 129, 1998
2. Aho, S., et al. J Cell Sci. 115: 1391, 2002
3. van Hengel, J., et al. Proc Natl Acad Sci U S A. 96: 7980,1999
