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p130Cas Antibody Phospho (pY410)

Rabbit Monoclonal Antibody

  • WB - p130Cas Antibody Phospho (pY410) AJ1564a
    Western blot analysis on HeLa cell lysates using anti-Phospho-p130Cas (pY410) RabMAb (Cat. #AJ1564a). Cells were either (A) untreated (B) treated with pervanadate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P56945
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1860
Calculated MW 93372 Da
Gene ID 9564
Other Names Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS
Target/Specificity A synthetic peptide corresponding to residues surrounding Tyrosine 410 of human p130Cas was used as an immunogen.
Dilution WB~~1:2500~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsp130Cas Antibody Phospho (pY410) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAR1
Synonyms CAS, CASS1, CRKAS
Function Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
Cellular Location Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
Tissue Location Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line
Research Areas
Citations (0)

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Breast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).


1. The UniProt Consortium. The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008). 2. Ruest PJ., et al. Mol Cell Biol. 21(22):7641-52, 2001 3. Bouton AH., et al. Oncogene 20(44):6448-58, 2001

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Cat# AJ1564a
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