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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   p21/Ras Antibody   

p21/Ras Antibody

Rabbit Monoclonal Antibody

  • WB - p21/Ras Antibody AJ1568b
    A. Western blot analysis on MCF7 cell lysate using anti-Ras/p21 RabMAb (Cat. #AJ1568b), dilution 1:500.
  • IHC - p21/Ras Antibody AJ1568b
    B. Immunohistochemical staining of HeLa cells using anti- Ras/p21 RabMAb (Cat. #AJ1568b)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01111
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y131
Calculated MW 21229 Da
Gene ID 4893
Other Names GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity A synthetic peptide corresponding to residues in the effector region of human Ras was used as an immunogen. Predicted to react with other Ras family members and cross-react with most species based on sequence homology.
Dilution WB~~1:2000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsp21/Ras Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HRAS1
Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus
Research Areas
Citations (0)

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Ras, a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30 % of all human cancer (4).


1. Ellis RW, et al. Nature. 1981 Aug 6; 292(5823):506
2. Campbell, S. L., (1998) Oncogene 17, 1395-1413
3. Zheng, Y., and Quilliam, L. A. (2003) EMBO Rep 4, 463-468
4. Bos JL. Cancer Res. 1989; 49:4682

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Cat# AJ1568b
(40 western blots)
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