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P2Y6 Antibody

Rabbit Monoclonal Antibody

  • WB - P2Y6 Antibody AJ1570a
    A. Western blot analysis on (A) A549, (B) HACAT, (C) HepG2 and (D) human spleen lysates using anti-P2Y6 RabMAb (Cat. #AJ1570a).
  • IHC - P2Y6 Antibody AJ1570a
    B.Immunohistochemical analysis of paraffin-embedded human kidney using anti-P2Y6 RabMAb (Cat. #AJ1570a).
  • IHC - P2Y6 Antibody AJ1570a
    C.Immunohistochemical analysis of paraffin-embedded human liver using anti-P2Y6 RabMAb (Cat. #AJ1570a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15077
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3816
Calculated MW 36429 Da
Gene ID 5031
Other Names P2Y purinoceptor 6, P2Y6, P2RY6
Target/Specificity A synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.
Dilution WB~~1:20000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsP2Y6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RY6
Function Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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P2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3).


1. Communi et al, Biochem Biophys Res Commun. 222(2):303-8, 1996. 2. von Kugelgen I., et al. Naunyn Schmiedebergs Arch Pharmacol. 362(4-5):310-23, 2000. 3. Liu GD., et al. Neurosci Bull. 25(3):161-4, 2009.

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Cat# AJ1570a
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