|Application ||WB, IHC|
|Calculated MW||36429 Da|
|Other Names||P2Y purinoceptor 6, P2Y6, P2RY6|
|Target/Specificity||A synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2Y6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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P2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3).
1. Communi et al, Biochem Biophys Res Commun. 222(2):303-8, 1996. 2. von Kugelgen I., et al. Naunyn Schmiedebergs Arch Pharmacol. 362(4-5):310-23, 2000. 3. Liu GD., et al. Neurosci Bull. 25(3):161-4, 2009.
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