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p73 Antibody

Rabbit Monoclonal Antibody

  • WB - p73 Antibody AJ1578a
    A. Western blot analysis of anti p73 RabMAb (Cat. #AJ1578a). dilution 1: 2,000 A: Hela B: Jurkat C: NIH 3T3
  • IHC - p73 Antibody AJ1578a
    B. Immunohistochemical analysis of paraffin-embedded human urinary bladder carcinoma using anti-p73 RabMAb RabMAb (Cat. #AJ1578a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15350
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP436Y
Calculated MW 69623 Da
Gene ID 7161
Other Names Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73
Target/Specificity A synthetic peptide corresponding to residues near the transactivation domain of human p73 was used as immunogen. p73 has a predicted molecular weight of 73 kDa but is detected at 63kDa.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsp73 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP73
Synonyms P73
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Cellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
Tissue Location Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue
Research Areas
Citations (0)

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p73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over- expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (α, β, and γ) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).


1. Kaghad et al. Cell 90: 809-819, 1997.
2. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D., and McKeon, F. (1998) Mol. Cell 2, 305-316
3. Marin MC, Jost CA, DeCaprio JA, Caput D, Kaelin WG Jr. Mol Cell Biol 1998;18:6316-24
4. Levrero, M., De Laurenzi, V., Costanzo, A., Gong, J., Melino, G., and Wang, J. Y. (1999) Cell Death Differ. 6, 1146-1153
5. Marin et al. Nature Genet. 25: 47-54, 2000.

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Cat# AJ1578a
(40 western blots)
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