|Application ||WB, IHC|
|Calculated MW||44706 Da|
|Other Names||Paired box protein Pax-2, PAX2|
|Target/Specificity||A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.|
|Tissue Location||Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).
1. Valentina Fonsato, et al. American Journal of Pathology 168(2), 2006
2. Cai Q, et al. Proc Natl Acad Sci U S A. 102(2):503-8, 2005
3. Antoni Hurtado, et al. Nature 456, 663-666, 2008
4. Phaikasame Sanyanusin, et al. Nature Genetics 9,358-364, 1995
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