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PAX2 Antibody

Rabbit Monoclonal Antibody

  • WB - PAX2 Antibody AJ1589a
    A. Western blot analysis on fetal kidney lysate using anti-PAX2 RabMAb (Cat. #AJ1589a), dilution 1:10,000.
  • IHC - PAX2 Antibody AJ1589a
    B.Immunohistochemical analysis of paraffin-embedded human fetal kidney using anti-PAX2 RabMAb (Cat. #AJ1589a).
  • IHC - PAX2 Antibody AJ1589a
    C.Immunohistochemical analysis of paraffin-embedded human normal kidney using anti-PAX2 RabMAb (Cat. #AJ1589a).
  • IHC - PAX2 Antibody AJ1589a
    D. Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma using anti-PAX2 RabMAb (Cat. #AJ1589a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02962
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP3251
Calculated MW 44706 Da
Gene ID 5076
Other Names Paired box protein Pax-2, PAX2
Target/Specificity A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX2
Function Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
Cellular Location Nucleus.
Tissue Location Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system
Research Areas
Citations (0)

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PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).


1. Valentina Fonsato, et al. American Journal of Pathology 168(2), 2006
2. Cai Q, et al. Proc Natl Acad Sci U S A. 102(2):503-8, 2005
3. Antoni Hurtado, et al. Nature 456, 663-666, 2008
4. Phaikasame Sanyanusin, et al. Nature Genetics 9,358-364, 1995

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Cat# AJ1589a
(40 western blots)
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