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PAX5 Antibody

Rabbit Monoclonal IgG

  • WB - PAX5 Antibody AJ1590a
    Western blot analysis on (A) Ramos and (B) Daudi cell lysates using anti-PAX5 RabMAb (Cat. #AJ1590a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02548
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3729
Calculated MW 42149 Da
Gene ID 5079
Other Names Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5
Target/Specificity A synthetic peptide corresponding to residues in human PAX5 was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX5
Function May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The human paired box protein Pax-5 (PAX5) is a member of the paired box domain family of transcription factors that play a role in B-cell differentiation, neural development, and spermatogenesis (1). As a result, its expression is detected in the developing central nervous system (CNS) and testis (1). In particular, PAX5 is essential for maintaining the identity and function of mature B cells during late B lymphopoiesis (2). The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation (3). During B-cell differentiation, PAX5 interacts with DAXX, a bridge protein that helps PAX5 to function as both a transcriptional activator and a repressor (4). A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia (1).


1. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 2. Lazzi S et al. Hum Pathol. 40(9):1252-61, 2009. 3. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins U, Baltimore, MD. MIM Number: {167414}: {5/27/2008}:WWW URL: 4. Emelyanov AV et al. J Biol Chem. 277(13):11156-64, 2002.

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Cat# AJ1590a
(40 western blots)
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