|Reactivity||Human, Mouse, Rat|
|Calculated MW||56896 Da|
|Other Names||Paired box protein Pax-7, HuP1, PAX7, HUP1|
|Target/Specificity||A synthetic peptide corresponding to residues in human PAX7 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.|
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Provided below are standard protocols that you may find useful for product applications.
The human paired box protein Pax-7 (PAX7) gene is a member of the paired box containing gene family of transcription factors implicated in development of the skeletal muscle of the trunk and limbs as well as elements of the central nervous system (1). PAX7 plays diverse roles during development, functioning in the developing central nervous system, neural crest, dermomyotome, and myotome and in specification of satellite cells, critical for adult muscle regeneration. Expression studies show that PAX7 is also transcribed in several adult tissues, including skeletal muscle and brain, suggesting that PAX7 may be involved in maintenance of programs of myogenic and neurogenic cells in adult tissues (1). In addition to playing a role in embryogenesis, PAX7 appears to be of importance in a number of diverse human diseases and cancers (2).
1. Syagailo Yana V., et al. Gene 294(1-2):259-268, 2002 2. Eugene Vorobyova and J黵gen Horst, Gene 342 (1):107-112, 2004
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