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PDZK1 Antibody

Rabbit Monoclonal Antibody

  • WB - PDZK1 Antibody AJ1599a
    Western blot analysis on (A) fetal liver and (B) fetal kidney lysates using anti-PDZK1 RabMAb (Cat. #AJ1599a).
  • IHC - PDZK1 Antibody AJ1599a
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti- PDZK1 RabMAb (Cat. #AJ1599a).
  • IF - PDZK1 Antibody AJ1599a
    Immmunofluorescent staining of HeLa cells using anti-PDZK1 RabMAb (Cat. #AJ1599a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5T2W1
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3751
Calculated MW 57129 Da
Gene ID 5174
Other Names Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, PDZK1, CAP70, NHERF3, PDZD1
Target/Specificity A synthetic peptide corresponding to residues in human PDZK1 was used as an immunogen.
Dilution WB~~1:5000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDZK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDZK1
Synonyms CAP70, NHERF3, PDZD1
Function A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity).
Tissue Location Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
Research Areas
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PDZ domain-containing protein 1 (PDZK1) is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells (1). PDZK1 is suggested to play multiple roles in normal physiology and may influence associated disorders. It is involved in maintaining hepatic SR-BI levels and controlling HDL metabolism, protects against the development of atherosclerosis and also mediates SR-BI-dependent regulation of endothelial cell biology by HDL (2). PDZK1 expression is limited to epithelial cells, located in the kidney, pancreas, liver, and small intestine. It is also expressed at a lower level in the adrenal cortex, testis and stomach, and it is over-expressed in breast, renal and lung carcinomas (1).


1. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res., 36:D190-D195 (2008). 2. Kocher O, et al. Curr Opin Lipidol. 20(3):236-41, 2009

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Cat# AJ1599a
(40 western blots)
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