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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Peroxiredoxin-6 Antibody   

Peroxiredoxin-6 Antibody

Rabbit Monoclonal

  • WB - Peroxiredoxin-6 Antibody AJ1600a
    Western blot analysis on A) HeLa, B) 293, and C) fetal liver lysates using anti- Peroxiredoxin 6 RabMAb (Cat. #AJ1600a)
  • IHC - Peroxiredoxin-6 Antibody AJ1600a
    Immunohistochemical analysis of paraffin-embedded human brain using anti-Peroxiredoxin 6 RabMab (2726-1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30041
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3754
Calculated MW 25035 Da
Gene ID 9588
Other Names Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, 311-, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12, PRDX6, AOP2, KIAA0106
Target/Specificity A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPeroxiredoxin-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDX6
Synonyms AOP2, KIAA0106
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
Cellular Location Cytoplasm. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}
Research Areas
Citations (0)

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Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation, differentiation, and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs, with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically, Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2).


1. Wood ZA, et al., Trends in Biochemical Science, 28(1):32-40, 2003. 2. Manevich Y, Fisher AB. Free Radic Biol Med. 38(11):1422-1432, 2005.

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Cat# AJ1600a
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