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Phospholamban Antibody Phospho (pS16)

Rabbit Monoclonal Antibody

  • WB - Phospholamban Antibody Phospho (pS16) AJ1604a
    Western blot analysis on fetal heart lysates using anti-Phospholamban Phospho (pS16) RabMAb (Cat. #AJ1604a). Cells were either (A) untreated (B) treated with LP.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P26678
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR1911
Calculated MW 6109 Da
Gene ID 5350
Other Names Cardiac phospholamban, PLB, PLN, PLB
Target/Specificity A phospho specific peptide corresponding to residues surrounding Serine 16 of human Phospholamban was used as an immunogen.
Dilution WB~~1:200000~500000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospholamban Antibody Phospho (pS16) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLN
Synonyms PLB
Function Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Cellular Location Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Heart muscle (at protein level).
Research Areas
Citations (0)

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Phospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1).


1. Fujii, et al. J. Biol. Chem., 266(18):11669-11675, 1991. 2. Wegener et al, J Biol Chem. 1989; 264:11468-11474.

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Cat# AJ1604a
(40 western blots)
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