|Calculated MW||46529 Da|
|Other Names||Serine/threonine-protein kinase 26, MST3 and SOK1-related kinase, Mammalian STE20-like protein kinase 4, MST-4, STE20-like kinase MST4, Serine/threonine-protein kinase MASK, STK26 (HGNC:18174)|
|Target/Specificity||A phospho specific peptide corresponding to residues surrounding threonine 178 of human MST4, theonine 190 of human MSt 3 and threonine 174 of human STK25.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-Mst4 (pT178)/Mst3 (pT190)/STK25 (pT174) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediator of cell growth. Modulates apoptosis.|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
Novel human Ste20-related kinase Mst4 is highly expressed in placenta, thymus, and peripheral blood leukocytes. Mst4 is biologically active in the activation of MEK/ERK pathway and in mediating cell growth and transformation (1). Wild type and C-terminally truncated forms of Mst4 can both induce apoptosis upon overexpression in mammalian cells that is abrogated by CrmA, suggesting involvement of Mst4 in the apoptotic machinery in mammalian cells (2). Mst4 was found to be expressed in prostate carcinoma tumor samples and cell lines. In addition, expression levels appeared to correlate with tumorigenicity and androgen receptor status of the cells. Mst4 kinase activity was stimulated significantly by epidermal growth factor receptor ligands, which are known to promote growth of prostate cancer cells (3).
1. Lin JL, et al. Oncogene 20(45):6559-69, 2001
2. Dan I, et al. J Biol Chem 277(8):5929-39, 2002
3. Sung V, et al. Cancer Res 63(12):3356-63, 2003
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