|Application ||WB, IHC|
|Calculated MW||87157 Da|
|Other Names||Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-term of human PLAP was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the maintenance of ubiquitin levels.|
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Provided below are standard protocols that you may find useful for product applications.
Phospholipase A2 activator protein (PLAP), activates PLA2 (phospholipase A2 enzyme) and is an important mediator of eicosanoid generation. Also known as a pro-inflammatory agent, PLAP has been found in inflamed tissues and synovial fluid from patients with rheumatoid arthritis. As such, it is believed to play an important role in the regulation of inflammatory diseases. The formation of PLAP can be stimulated by IL-1 beta and TNF-alpha (1-2).
1. Clark, M. A., T. M. Conway, R. G. L. Shorr, and S. T. Crooke. 1987. J. Biol. Chem. 262:4402
2. Chopra, A. K.; Ribardo, D. A.; Wood, T. G.; Prusak, D. J.; Xu, X.-J.; Peterson, J. W. : Biochim. Biophys. Acta 1444: 125-130, 1999.
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