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PLC II Antibody Phospho (pY1217)

Rabbit Monoclonal Antibody

  • WB - PLC II Antibody Phospho (pY1217) AJ1629b
    A. Western blot analysis on Raji cell lysates using anti-Phospho- PLC?II (pY1217) RabMAb (Cat. #AJ1629b). Cells were either (A) untreated (B) treated with pervanadate.
  • IHC - PLC II Antibody Phospho (pY1217) AJ1629b
    B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-Phospho- PLC?II (pY1217) RabMAb (Cat. #AJ1629b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16885
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1404Y
Calculated MW 147870 Da
Gene ID 5336
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2, PLCG2
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding Tyr1217 of human PLCγII was used as immunogen. The antibody only detects PLCγII phosphorylated onTyrosine 1217.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLC II Antibody Phospho (pY1217) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCG2
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Research Areas
Citations (0)

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Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCγII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate (1). PLCγII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCγII (2). It has also been shown that PLCγII was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1), activator protein-1 (AP1), and NF-kappaB (3).


1. Argeson AC, et al. Genomics 25(1):29-35, 1995.
2. Ozdener F, et al. Mol Pharmacol 62(3):672-9, 2002.
3. Mao D, et al. J Clin Invest 166(11):2869-79, 2006.

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Cat# AJ1629b
(40 western blots)
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