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PLCI Antibody Phospho (pY783)

Rabbit Monoclonal Antibody

  • WB - PLCI Antibody Phospho (pY783) AJ1631c
    A. Western blot analysis on Jurkat cell lysates using anti-Phospho- PLC gamma 1 (pY783) RabMAb (Cat. #AJ1631c), 1:10,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19174
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2611Y
Calculated MW 148532 Da
Gene ID 5335
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1, PLC1
Target/Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 783 of human PLCgamma1 was used as an immunogen. This antibody detects PLCgamma1 phosphorylated on tyrosine 783.
Dilution WB~~1:50000~100000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLCI Antibody Phospho (pY783) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCG1
Synonyms PLC1
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Cellular Location Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment
Research Areas
Citations (0)

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Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups (1). Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain (2). Also, results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry (3). Insulin increased PLCgamma1 tyrosine phosphorylation at Tyr-783 and its colocalization with the IR in punctated structures enriched in cortical actin at the dorsal plasma membrane. This association was found to be independent of PLCgamma1 Src homology 2 domains (4).


1. Argeson AC, et al. Genomics 25(1):29-35, 1995
2. Ye, K, et al. Nature 415(6871):514-4, 2002
3. Patterson RL, et al Cell, 111(4):529-41, 2002
4. Kwon YK et al. J Cell Biol 163(2):375-84, 2003

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Cat# AJ1631c
(40 western blots)
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