|Reactivity||Human, Mouse, Rat|
|Calculated MW||18942 Da|
|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human Pleiotrophin was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Precautions||Pleiotrophin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Pleiotrophin (PTN) is the first member of a recently discovered family of developmentally regulated cytokines. This protein, previously designated heparin-binding growth factor-8, was renamed pleiotrophin to reflect its diverse activities (1). PTN is a member of a highly conserved human gene family of proteins. It has a high affinity for heparin and exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth (2). More recently, PTN was found to be overexpressed in a variety of neuroectodermal tumors and described as an essential angiogenic growth factor in choriocarcinoma and melanoma, promoting metastatic growth. High expression levels of PTN were also found in patients with gastrointestinal malignancies, particularly in those patients with pancreatic cancer (3)
1. Li YS, et al. Science 250(4988):1690-4, 1990
2. Eddy R, et al. Cytogenet Cell Genet 58, 1920, 1991
3. Weber D, et al. Cancer Res 60(18):5284-8, 2000
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