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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Pleiotrophin Antibody   

Pleiotrophin Antibody

Rabbit Monoclonal Antibody

  • WB - Pleiotrophin Antibody AJ1636a
    A.Western blot analysis on lysates (A) NIH/3T3 treated with 2% FBS cell lysate and (B) fetal brain tissue lysate using anti-pleiotrophin RabMAb (Cat. #AJ1636a), dilution 1:20,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21246
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3041
Calculated MW 18942 Da
Gene ID 5764
Other Names Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Pleiotrophin was used as immunogen.
Dilution WB~~1:10000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPleiotrophin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTN
Synonyms HBNF1, NEGF1
Function Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation.
Cellular Location Secreted.
Tissue Location Osteoblast and brain.
Research Areas
Citations (0)

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Pleiotrophin (PTN) is the first member of a recently discovered family of developmentally regulated cytokines. This protein, previously designated heparin-binding growth factor-8, was renamed pleiotrophin to reflect its diverse activities (1). PTN is a member of a highly conserved human gene family of proteins. It has a high affinity for heparin and exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth (2). More recently, PTN was found to be overexpressed in a variety of neuroectodermal tumors and described as an essential angiogenic growth factor in choriocarcinoma and melanoma, promoting metastatic growth. High expression levels of PTN were also found in patients with gastrointestinal malignancies, particularly in those patients with pancreatic cancer (3)


1. Li YS, et al. Science 250(4988):1690-4, 1990
2. Eddy R, et al. Cytogenet Cell Genet 58, 1920, 1991
3. Weber D, et al. Cancer Res 60(18):5284-8, 2000

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Cat# AJ1636a
(40 western blots)
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