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Plexin-A1 Antibody

Rabbit Monoclonal Antibody

     
  • WB - Plexin-A1 Antibody AJ1637a
    Western blot analysis on (A) K562 (B) 293T (C) HUVEC (D) HepG2 cell lysates and (E) Fetal Brain tissue lysates using anti-Plexin-A1 RabMAb (Cat. #AJ1637a).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9UIW2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3449
Calculated MW 211067 Da
Gene ID 5361
Other Names Plexin-A1, Semaphorin receptor NOV, PLXNA1, NOV, PLXN1
Target/Specificity A synthetic peptide corresponding to residues in human Plexin-A1 was used as an immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPlexin-A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLXNA1
Synonyms NOV, PLXN1
Function Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Detected in fetal brain, lung, liver and kidney.
Research Areas
Citations (0)

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Background

Plexins are large transmembrane receptors for semaphorins. It contains a sema domain and a highly conserved cytoplasmic domain (1). Plexins are classified into four groups: A, B, C, D. Plexin-A1 is a co-receptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A1 plays a role in axon guidance, invasive growth and cell migration. Plexin-A1 modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (2). Plexin-A1 is specific in fetal brain, lung, liver and kidney (3).

References

1. Artigianis, et al. EMBO Reports 5,7:710-714 (2004) 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008). 3. Tamagnone L, et al. Cell 99(1):71-80, 1999

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Discontinued
Cat# AJ1637a
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