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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PON-1 Antibody   

PON-1 Antibody

Rabbit Monoclonal IgG

     
  • WB - PON-1 Antibody AJ1640a
    Western blot analysis on (A) human plasma cell and (B) ovary cancer lysates using anti-PON 1 RabMAb (Cat. #AJ1640a).
  • IHC - PON-1 Antibody AJ1640a
    Immunohistochemical staining of paraffin-embedded human liver tissue using anti-PON 1 RabMAb (Cat. #AJ1640a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P27169
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2892
Calculated MW 39731 Da
Gene ID 5444
Other Names Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus in human PON 1 was used as an immunogen.
Dilution WB~~1:1000~10000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPON-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PON1
Synonyms PON
Function Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Cellular Location Secreted, extracellular space.
Tissue Location Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas
Research Areas
Citations (0)

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Background

Paraoxonase 1 (PON 1) is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins (HDL) (1, 3). It hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides and nerve agents (2). This protein has been implicated in protection from atherosclerosis (2). PON 1 possesses both antioxidant and anti-inflammatory properties (1, 3). Protecting LDL and HDL from lipid peroxidation, PON 1 degrades specific oxidized cholesteryl esters and oxidized phospholipids contained in lipoproteins (1, 3, 4).

References

1. Camps et al. World J Gastroenterol. 15(16):1929-33, 2009. 2. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: {168820}: {7/30/2009}: . World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/ 3. J Clin Biochem Nutr. 45(3):278-84, 2009. 4. Getz et al. Curr Opin Lipidol. 15(3):261-7, 2004.

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Discontinued
Cat# AJ1640a
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