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PRC1 Antibody

Rabbit Monoclonal Antibody

  • WB - PRC1 Antibody AJ1648a
    A. Western blot analysis on HeLa cell lysate using anti-PRC1 RabMAb (Cat. #AJ1648a), dilution 1:10,000.
  • IHC - PRC1 Antibody AJ1648a
    B. Immunohistochemical staining of paraffin-embedded human cervical carcinoma using anti-PRC1 RabMAb (Cat. #AJ1648a).
  • IF - PRC1 Antibody AJ1648a
    C. Immunofluorescent staining of HeLa cells using anti-PRC1 RabMAb (Cat. #AJ1648a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BSB6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1513Y
Other Names PRC1, Protein regulator of cytokinesis 1
Target/Specificity A synthetic peptide corresponding to residues on human PRC1 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Citations (0)

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Novel human protein Protein regulator of cytokinesis 1 (PRC1) is involved in cytokinesis. PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in vivo CDK substrate. PRC1 protein levels are high during S and G2/M and drop dramatically after cells exit mitosis and enter G1. PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis (1). PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in vitro. Overexpression of PRC1 extensively bundles interphase microtubules, but does not affect early mitotic spindle organization (2). PRC1 has been shown to down-regulate the GAP activity of MgcRac-GAP during the metaphase and thereby contributes to the correct formation of the spindle (3).


1. Jiang W, et al. Mol Cell 2(6):877-85, 1998.
2. Mollinari C, et al. J. Cell Biol 157(7):1175-86, 2002.
3. Ban R, et al. J Biol Chem 279(16):16394-402, 2004.

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Cat# AJ1648a
(40 western blots)

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