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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Prealbumin Antibody   

Prealbumin Antibody

Rabbit Monoclonal Antibody

  • WB - Prealbumin Antibody AJ1649a
    A.Western blot analysis on (A) human heart, (B) human placenta and (C) human brain lysates using anti-PrealbuminRabMAb (Cat. #AJ1649a), dilution 1:5000.
  • IHC - Prealbumin Antibody AJ1649a
    B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Prealbumin RabMAb (Cat. #AJ1649a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02766
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2929Y
Calculated MW 15887 Da
Gene ID 7276
Other Names Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Prealbumin was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPrealbumin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTR
Synonyms PALB
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Cellular Location Secreted. Cytoplasm.
Tissue Location Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver
Research Areas
Citations (0)

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Transthyretin (prealbumin/TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Transthyretin concentrations are disproportionately high in human ventricular CSF. It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in transthyretin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of transthyretin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin fibrils (2). Transthyretin has a structural complementarity to double-helical DNA, where the proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms (1).


1. Blake CC, et al. Nature. 268(5616):115-20, 1977
2. Klabunde T, et al. Nat Struct Biol. 7(4):312-21, 2000
3. Herbert J, et al. Neurology 36(7):900-11, 1986
4. Saraiva MJ Hum Mutat. 17(6):493-503, 2001

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Cat# AJ1649a
(40 western blots)
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