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Presenilin-1 Antibody Phospho (pS310)

Rabbit Monoclonal Antibody

  • WB - Presenilin-1 Antibody Phospho (pS310) AJ1650c
    A. Western blot analysis on Jurkat cell lysates using anti-phospho Presenilin 1 (pS317) RabMAb (Cat. #AJ1650c), dilution 1:5000. Cells were either (A) untreated (B) treated with TPA.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49768
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2001Y
Calculated MW 52668 Da
Gene ID 5663
Other Names Presenilin-1, PS-1, 3423-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1
Target/Specificity A phospho specific peptide corresponding to residues surrounding serine 310 of human Presenilin 1 was used as an immunogen. This antibody detects Presenilin 1 phosphorylated on serine 310
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPresenilin-1 Antibody Phospho (pS310) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSEN1
Synonyms AD3, PS1, PSNL1
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils
Tissue Location Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes
Research Areas
Citations (0)

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Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). Phosphorylation at serine 310 by PKACa has been linked to its proteolytic processing and apoptosis regulation (3). Heterogenous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of 35 kDa and 20 kDa respectively. During apoptosis, CTF is further cleaved by caspase-3 to produce PSI-CTF12 fragment.


1. Steiner H, et al. J Biol Chem. 274(40):28669-73, 1999.
2. Kimberly WT, et al. J Biol Chem 275(5):3173-8, 2000.
3. Fluhrer R, et al., J Biol Chem 279:1585-1593, 2004

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Cat# AJ1650c
(40 western blots)
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