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Presenilin-2 AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1651a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Presenilin-2 Antibody - Product info | |
| Application | WB, IHC
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| Primary Accession | P49810 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EP1515Y |
| Calculated MW | 50140 Da |
| Gene ID 5664 | |
| Other Names PSEN2, AD4, PS2, PSNL2, STM2, Presenilin-2 CTF subunit, STM-2;E5-1;AD3LP;AD5 | |
| Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human Presenilin 2 was used as an immunogen. | |
| Dilution WB~~1:2000 IHC~~1:50~100 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Presenilin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Presenilin-2 Antibody - Protein Information | |
| Name PSEN2 | |
| Synonyms AD4, PS2, PSNL2, STM2 | |
| Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins | |
| Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein | |
| Tissue Location Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney | |
Presenilin-2 Antibody - Related products
AP6232a: Presenilin 2 (PSEN2) Antibody (N-term)
AP6304c: Presenilin 2/1 (PSEN2/PSEN1) Antibody (N-term)
AP6305a: Presenilin 2 (PSEN2) Antibody (C-term)
AP6305b: Presenilin 2 (PSEN2) Antibody (N-term)
RI14267: PSEN2 predesign siRNA
BP6232a: PSEN2 Antibody (N-term) Blocking Peptide
BP6304c: PSN2/1 Antibody (C-term) Blocking Peptide
BP6305a: PSN2 Antibody (C-term) Blocking Peptide
BP6305b: PSN2 Antibody (N-term) Blocking Peptide
AJ1651a: Presenilin-2 Antibody
Presenilin-2 Antibody - Application data
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A. Western blot analysis on PC-12 cell lysate using anti- Presenilin 2 RabMAb (Cat. #AJ1651a).
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B. Immunohistochemical staining of paraffin-embedded human kidney using anti-Presenilin 2 RabMAb (Cat. #AJ1651a).
Presenilin-2 Antibody - Research Areas
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BACKGROUND
Presenilin 1 (PS1) and Presenilin 2 (PS2) are transmembrane proteins which belong to Presenilin family, and their mutations are associated with early onset familial Alzheimer's disease. Presenilins facilitate gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Phosphorylation of the PS2 C-terminal fragments at serine residues 327 and 330, located immediately adjacent to the caspase recognition sites, inhibits caspase-mediated cleavage of PS2 and can regulate apoptotic cleavage. PS2 is cleaved by caspases during apoptosis between aspartate 329 and serine 330 (2).
REFERENCES
1. Steiner H, et al. J Biol Chem. 274(40):28669-73, 1999.
2. Walter J, et al. Proc Natl Acad Sci U S A 96:1391-6, 1999.
