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PRMT1 Antibody

Rabbit Monoclonal Antibody

  • WB - PRMT1 Antibody AJ1654a
    Western blot analysis on (A) A549 (B)HeLa and (C) NIH/3T3 cell lysates using anti-PRMT1 RabMAb (Cat. #AJ1654a).
  • IHC - PRMT1 Antibody AJ1654a
    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-PRMT1 RabMAb (Cat. #AJ1654a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99873
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR3292
Calculated MW 41516 Da
Gene ID 3276
Other Names Protein arginine N-methyltransferase 1, 211-, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, PRMT1, HMT2, HRMT1L2, IR1B4
Target/Specificity A synthetic peptide corresponding to residues in human PRMT1 was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRMT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRMT1
Synonyms HMT2, HRMT1L2, IR1B4
Function Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.
Cellular Location Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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PRMT1 is a member of the Protein arginine methyltransferases (PRMTs) family that regulates mRNA processing and maturation by modulating the activity of RNA-binding proteins through methylation (1). PRMTs have been implicated in a variety of processes, including cell proliferation, signal transduction, and protein trafficking. Eleven PRMTs have been identified in humans. Except for PRMT2, 10 and 11, all PRMTs have been shown to catalyze arginine methylation, with PRMT1, 4, 5, 7, 8 and 9 have the ability to also methylate histones (2). PRMT1 appears to be a major type I enzyme in embryonic stem cells, and in wild-type cells, most substrates of the enzyme appear to be maintained in a fully methylated state (3).


1. Scorilas A, et al. Biochem Biophys Res Comm 278(2): 349-59, 2000 2. Pal S, et al. Journal of Cell Physiology 213 (2) 306-315, 2007 3. Pawlak MR, et al. Mol Cell Biol 20(13):4895-69, 2000

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Cat# AJ1654a
(40 western blots)
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