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Progesterone Antibody

Rabbit Monoclonal Antibody

  • WB - Progesterone Antibody AJ1655a
    A. Western blot analysis on T47D cell lysate using anti-PR RabMAb (Cat. #AJ1655a), dilution 1:10,000.
  • IHC - Progesterone Antibody AJ1655a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-PR RabMAb (Cat. #AJ1655a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06401
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names YR85
Calculated MW 98981 Da
Gene ID 5241
Other Names Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
Target/Specificity A synthetic peptide corresponding to residues near N-terminus of human Progesterone Receptor was used as immunogen. The antibody does not cross-react with other NR3 family members.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsProgesterone Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGR
Synonyms NR3C3
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane
Research Areas
Citations (0)

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The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family (1). PR exists in humans as two isoforms; PR-A (94 kDa) which lacks the first 164 amino acids of PR-B and PR-B (114 kDa)(2-3). While the two forms of PR have similar DNA- and ligand-binding affinities they have opposite transcriptional activities. PR-B functions as an activator of progesterone-responsive genes, while PR-A functions as a strong transdominant repressor of PR-B (4)


1. Evans, R. M. 1988. The steroid and thyroid hormone receptor superfamily. Science 240:889-895
2. Paloma H. Giangrande, Erin A. Kimbrel Dean P. Edwards and Donald P. McDonnell, Molecular and Cellular Biology, May 2000, p. 3102-3115, Vol. 20, No. 9
3. Giangrande, P. H., G. Pollio, and D. P. McDonnell. 1997. Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. J. Biol. Chem. 272:32889-32900
4. B. Mulac-Jericevic and O. M Conneely. Reproductive tissue selective actions of progesterone receptors. Reproduction, August 1, 2004; 128(2): 139

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Cat# AJ1655a
(40 western blots)
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