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Prohibitin Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - Prohibitin Antibody (N-term) AJ1656b
    A. Western blot analysis on (A) MCF-7 (B) A431, (C) 293T and Ramos cells.
  • IHC - Prohibitin Antibody (N-term) AJ1656b
    B. Immunohistochemical analysis of paraffin-embedded human kidney tissues using anti-Prohibitin RabMAb
  • IHC - Prohibitin Antibody (N-term) AJ1656b
    C. Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Prohibitin RabMAb (Cat. #AJ1656b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35232
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP2803Y
Calculated MW 29804 Da
Gene ID 5245
Other Names Prohibitin, PHB
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human prohibitin was used as an immunogen.
Dilution WB~~1:10,000~20,000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsProhibitin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB
Function Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Cellular Location Mitochondrion inner membrane.
Tissue Location Widely expressed in different tissues.
Research Areas
Citations (0)

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Prohibitin (PHB) proteins have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging. It has been shown that the mammalian prohibitins are present in the inner mitochondrial membrane and are always bound to each other, with no free protein detectable. They are coexpressed during development and in adult mammalian tissues, and expression levels are indicative of a role in mitochondrial metabolism, but are not compatible with roles in the regulation of cellular proliferation or apoptosis. Data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging (1). Results suggest that prohibitin may be a tumor suppressor and is associated with tumor development and/or progression of at least some breast cancers (2).


1. Coates PJ, et al. Exp. Cell Res. 265(2):262-73, 2001
2. Sato T, et al. Cancer Res. 52(6):1643-6, 1992

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Cat# AJ1656b
(40 western blots)
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