|Calculated MW||25876 Da|
|Other Names||Prolactin, PRL, PRL|
|Target/Specificity||A synthetic peptide corresponding to residues in human Prolactin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Prolactin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Prolactin acts primarily on the mammary gland by promoting lactation.|
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Provided below are standard protocols that you may find useful for product applications.
Prolactin (PRL) is a peptide hormone secreted from the anterior pituitary gland, primarily associated with lactation. It plays an important role in the proliferation and differentiation of cells in mammary gland development (1, 2). It also participates in regulation of angiogenesis (3). PRL has more actions than all other pituitary hormones combined. The initial step in the action of PRL, like all other hormones, is the binding to a specific membrane receptor, the PRL receptor (PRLR). Pituitary PRL acts via a classic endocrine pathway (2). The PRL that is produced by many different cell types can act in a more direct fashion; i.e., as a growth factor, neurotransmitter or immunomodulator, in an autocrine or paracrine manner. Thus, locally produced PRL can act on adjacent cells (paracrine) or on the PRL-secreting cell itself (autocrine) in many tissues via the broad distribution of its receptors (2, 4).
1. Brisken et al. Dev. Cell. 3:877-887; 2002 2. Bole-Feysot et al. Endor. Rev. 19:225-268; 1998 3. Struman et al. Proc. Natl. Acad. Sci. USA 96:1246-1251; 1999 4. Goffin et al. Annu. Rev. Physiol. 64 :47-67 ; 2002
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