|Application ||WB, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||18697 Da|
|Other Names||Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP|
|Target/Specificity||A synthetic peptide corresponding to residues in human Prostaglandin E Synthase 3 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Prostaglandin-E Synthase 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).|
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Provided below are standard protocols that you may find useful for product applications.
Prostaglandin E synthase-3 belongs to p23/wos2 family. It is ubiquitously expressed. As one of the two isoforms of the terminal enzymes catalyzing the final step of EG2 biosynthesis, prostaglandin E synthase-3 predominantly converts COX-1-derived PGH2 to PGE2 (1). It is an evolutionarily conserved protein that functions as a component of the Hsp90-based molecular chaperone complex (2). It binds to telomerase and to the progesterone receptor (3). It localizes to genomic response elements in a hormone-dependent manner and represses receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes (4).
1. Nakatani et al, Nippon Yakurigaku Zasshi 2002; 120(6):373-8. 2. Felts et al, Cell Stress Chaperones 2003; 8:108-113. 3. Johnson et al, Mol Cell Biol. 1994; 14(3):1956-63. 4. Freeman et al, Science. 2002; 296(5576):2232-5.
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