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Prostaglandin-E Synthase 3 Antibody

Rabbit Monoclonal Antibody

  • WB - Prostaglandin-E  Synthase 3 Antibody AJ1658a
    A.Western blot analysis on (A) HeLa, (B) human spleen, (C) Jurkat and (D) HepG2 cell lysates using anti-Prostaglandin E Synthase 3 RabMAb (Cat. #AJ1658a).
  • IF - Prostaglandin-E  Synthase 3 Antibody AJ1658a
    B.Immunofluorescent staining of HeLa cells using anti-Prostaglandin E Synthase 3 RabMAb (Cat. #AJ1658a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15185
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3846
Calculated MW 18697 Da
Gene ID 10728
Other Names Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP
Target/Specificity A synthetic peptide corresponding to residues in human Prostaglandin E Synthase 3 was used as an immunogen.
Dilution WB~~1:100000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsProstaglandin-E Synthase 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms P23, TEBP
Function Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Prostaglandin E synthase-3 belongs to p23/wos2 family. It is ubiquitously expressed. As one of the two isoforms of the terminal enzymes catalyzing the final step of EG2 biosynthesis, prostaglandin E synthase-3 predominantly converts COX-1-derived PGH2 to PGE2 (1). It is an evolutionarily conserved protein that functions as a component of the Hsp90-based molecular chaperone complex (2). It binds to telomerase and to the progesterone receptor (3). It localizes to genomic response elements in a hormone-dependent manner and represses receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes (4).


1. Nakatani et al, Nippon Yakurigaku Zasshi 2002; 120(6):373-8. 2. Felts et al, Cell Stress Chaperones 2003; 8:108-113. 3. Johnson et al, Mol Cell Biol. 1994; 14(3):1956-63. 4. Freeman et al, Science. 2002; 296(5576):2232-5.

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Cat# AJ1658a
(40 western blots)
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