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Pumilio-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Pumilio-1 Antibody AJ1667a
    Western blot analysis on (A) HeLa (3 min. exposure) and (B) 293T cell lysates using anti-Pumilio-1 RabMAb (Cat. #AJ1667a).
  • IHC - Pumilio-1 Antibody AJ1667a
    Immunohistochemical analysis of paraffin-embedded human fetal kidney tissue using anti-Pumilio 1 RabMAb (Cat. #AJ1667a).
  • IF - Pumilio-1 Antibody AJ1667a
    Immunofluorescent staining of HeLa cells using anti-Pumilio 1 RabMAb (Cat. #AJ1667a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14671
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR3795
Calculated MW 126473 Da
Gene ID 9698
Other Names Pumilio homolog 1, HsPUM, Pumilio-1, PUM1, KIAA0099, PUMH1
Target/Specificity A synthetic peptide corresponding to residues in human Pumilio-1 was used as an immunogen. This antibody is predicted to not cross react with Pumilio-2.
Dilution WB~~1:10000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPumilio-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUM1
Synonyms KIAA0099, PUMH1
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells.
Cellular Location Cytoplasm.
Tissue Location Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested
Research Areas
Citations (0)

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Pumilio-1 is a sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. It belongs to the PUF family, 84% identical to Pumilio-1. It is required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (1). Pumilio-1 is highly expressed in testis and ovary and is predominately expressed in stem cells and germ cells.


1. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008) 2. Wang X, et al. Mol Cell 7(4) :855-65, 2001

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Cat# AJ1667a
(40 western blots)
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