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Pumilio-2 Antibody

Rabbit Monoclonal Antibody

  • WB - Pumilio-2 Antibody AJ1668a
    Western blot analysis on (A) HeLa and (B) 293T cell lysates using anti-Pumilio-2 RabMAb (Cat. #AJ1668a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TB72
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3813
Calculated MW 114216 Da
Gene ID 23369
Other Names Pumilio homolog 2, Pumilio-2, PUM2, KIAA0235, PUMH2
Target/Specificity A synthetic peptide corresponding to residues in human Pumilio-2 was used as an immunogen. This antibody is predicted to not cross react with Pumilio-1.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPumilio-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUM2
Synonyms KIAA0235, PUMH2
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
Cellular Location Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
Tissue Location Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen Expressed in all fetal tissues tested
Research Areas
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Pumilio-2 is a sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. It belongs to the PUF family, 84% identical to Pumilio-1. It is required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (1). Pumilio-2 is highly expressed in testis and ovary and is predominately expressed in stem cells and germ cells.


1. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)

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Cat# AJ1668a
(40 western blots)
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