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Radixin Antibody

Rabbit Monoclonal Antibody

  • WB - Radixin Antibody AJ1672a
    A. Western blot analysis on HeLa cell lysate using anti-Radixin RabMAb (Cat. #AJ1672a), dilution 1:20,000.
  • IHC - Radixin Antibody AJ1672a
    B. Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti-Radixin RabMAb (Cat. #AJ1672a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35241
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1862Y
Calculated MW 68564 Da
Gene ID 5962
Other Names Radixin, RDX
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Radixin was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRadixin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RDX
Function Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively
Research Areas
Citations (0)

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Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).


1. Wilgenbus KK, et al. Genomics 16(1):199-206, 1993
2. Kikuchi S, et al. Nat Genet 31(3):320-5, 2002
3. Pataky F, et al. Proc Natl Acad 101(8):2601-6, 2004

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Cat# AJ1672a
(40 western blots)
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