|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||68564 Da|
|Other Names||Radixin, RDX|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human Radixin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Radixin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively|
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Provided below are standard protocols that you may find useful for product applications.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).
1. Wilgenbus KK, et al. Genomics 16(1):199-206, 1993
2. Kikuchi S, et al. Nat Genet 31(3):320-5, 2002
3. Pataky F, et al. Proc Natl Acad 101(8):2601-6, 2004
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