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RanBP9 Antibody (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1675a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
RanBP9 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q96P70 |
| Reactivity | Human, Mouse |
| Clone Names | EP1353Y |
| Calculated MW | 115963 Da |
| Gene ID 55705 | |
| Other Names IPO9, IMP9, KIAA1192, RANBP9, Importin-9, Ran-binding protein 9 | |
| Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human RANBP9 was used as an immunogen. | |
| Dilution WB~~1:100000~200000 IHC~~1:50 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RanBP9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RanBP9 Antibody (C-term) - Protein Information | |
| Name IPO9 | |
| Synonyms IMP9, KIAA1192, RANBP9 | |
| Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6 | |
| Cellular Location Cytoplasm (By similarity). Nucleus (By similarity) | |
RanBP9 Antibody (C-term) - Related products
AP5564a: IPO9 Antibody (N-term)
RanBP9 Antibody (C-term) - Application data
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A. Western blot analysis on fetal brain lysate using anti-RanBP9 RabMAb (Cat. #AJ1675a), dilution 1:1000.
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B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-RanBP9 RabMAb (Cat. #AJ1675a).
RanBP9 Antibody (C-term) - Research Areas
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BACKGROUND
Just as heat shock proteins function as chaperones for exposed hydrophobic patches, importins act as chaperones for exposed basic domains, and it is suggested that this represents a major and general cellular function of importins (1). RanBP9, a novel interacting protein, was localized within the centrosome throughout the cell cycle. Overexpression of RanBP9 produced multiple spots which were colocalized with gamma-tubulin and acted as ectopic microtubule nucleation sites, resulting in a reorganization of microtubule network (2).
REFERENCES
1. Jakel S, et al. EMBO J 21(3):377-86, 2002.
2. Nakamura M, et al. J. Cell Bio 143(4):1041-52, 1998.
