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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RanGAP1 Antibody   

RanGAP1 Antibody

Rabbit Monoclonal Antibody

  • WB - RanGAP1 Antibody AJ1676a
    Western blot analysis on (A) HeLa, (B) MCF-7, (C) SH-SY5Y and (D) A549 cell lysates using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IHC - RanGAP1 Antibody AJ1676a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IHC - RanGAP1 Antibody AJ1676a
    Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IF - RanGAP1 Antibody AJ1676a
    Immunofluorescent staining of HeLa cells using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46060
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3295
Calculated MW 63542 Da
Gene ID 5905
Other Names Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity A synthetic peptide corresponding to residues in human RanGAP1 was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRanGAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1835, SD
Function GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Cellular Location Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase Mitotic location also requires sumoylation
Tissue Location Highly expressed in brain, thymus and testis.
Research Areas
Citations (0)

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RanGAP1 is the activator of the Ras-related nuclear GTPase Ran, which is involved in the nucleo-cytoplasmic transport, mitotic spindle assembly, cell cycle control and nuclear envelope (NE) formation (1, 2). Its roles are accomplished by the asymmetric distribution of its GTP- and GDP-bound forms, enabled by the specific localization of Ran accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC. Mammalian RanGAP1 is targeted to the NE during interphase and to the spindle and kinetochores during mitosis via SUMOylated C-terminal domain and interaction with the nucleoporin Nup358/RanBP2 (2). RanGAP1 is highly expressed in brain, thymus and testis (3).


1. Krebber H., et al. Gene 180:7-11, 1996 2. Meier I, et al. J Microsc. 231(2):225-33, 2008 3. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195(2008)

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Cat# AJ1676a
(40 western blots)
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