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Rheb Antibody

Rabbit Monoclonal Antibody

  • WB - Rheb Antibody AJ1687a
    A. Western blot analysis on (A) Raji and (B) SH-SY5Y cell lysates using anti-Rheb RabMAb (Cat. #AJ1687a), dilution 1:2000.
  • IHC - Rheb Antibody AJ1687a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Rheb RabMAb (Cat. #AJ1687a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15382
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2971
Calculated MW 20497 Da
Gene ID 6009
Other Names GTP-binding protein Rheb, Ras homolog enriched in brain, RHEB, RHEB2
Target/Specificity A synthetic peptide corresponding to residues in human Rheb was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRheb Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RHEB2
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Cellular Location Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Research Areas
Citations (0)

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Rheb (Ras Homolog Enriched in brain) is a Ras-like small guanosine triphosphatase (GTPase) that is involved in cell growth and cell cycle progression. Rheb has also been suggested to have involvement in the TOR/S6K signaling pathway (1). It regulates the activity of the mammalian target of rapamycin, mTOR, a central regulator of cell growth, in response to growth factor stimulation and nutrient availability (2). It also interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, and is suggested to function in concert with H-Ras to dynamically integrate cAMP and growth factor signaling (3).


1. Tabancay AP Jr, et al. J Biol Chem. 278(41):39921-30, 2003
2. Hsu YC, et al. Nature. 445(7129):785-8, 2007
3. Bai X, et al. Science. 318(5852):977-80, 2007
4. WM Yee, et al. Mol. Cell. Biol. 17(2):921-933, 1997

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Cat# AJ1687a
(40 western blots)
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