|Application ||WB, FC|
|Calculated MW||104757 Da|
|Other Names||Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2, ROR2, NTRKR2|
|Target/Specificity||A synthetic peptide corresponding to residues of human ROR2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ROR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a tyrosine protein kinase receptor which is required for cartilage and growth plate development. As a member of the receptor protein kinases (RTKs) family, ROR2 is commonly found in embryonic kidney, but its function has not been fully understood. ROR2 has been linked to embryonic development due its involvement in WNT signaling pathway. Additionally, ROR2 has been shown to be critical for the formation of skeleton, heart, and genitals. Specifically, ROR2 phosphorylates 14-3-3 protein beta/alpha which leads to induction of osterogenesis and bone formation (2). A mutation in ROR2 is commonly seen in Robinow syndrome and autosomal dominant brachydactyly B disorders (3).
1. Smithgall TE et al., Crit. Rev. Oncog. 9:43-62, 1998. 2. Liu Y et al., Molecular Endocrinology 21(12):3050-3061, 2007. 3. Oldridge M. et al. Nature Genetics 24:275 - 278, 2000.
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