|Application ||WB, IHC|
|Calculated MW||83872 Da|
|Other Names||Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, 90 kDa ribosomal protein S6 kinase 6, p90-RSK 6, p90RSK6, Ribosomal S6 kinase 4, RSK-4, pp90RSK4, RPS6KA6, RSK4|
|Target/Specificity||A synthetic peptide corresponding to residues surrounding serine 235 of human Rsk 4 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RSK4 Antibody Phospho (pS235) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic|
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Provided below are standard protocols that you may find useful for product applications.
RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3).
1. Moller, D.E., et al. Am J Physiol. 266(2 Pt 1): C351
2. Frodin, M., et al. Mol. Cell. Endocrinol. 151: 65
3. Yntema HG, et al. Genomics 62(3):332-43, 1999.
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