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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   S100 beta Antibody (C-term)   

S100 beta Antibody (C-term)

Rabbit Monoclonal Antibody

  • IHC - S100 beta Antibody (C-term) AJ1702a
    B. Immunohistochemical analysis of paraffin-embedded human melanoma using anti- S100-beta RabMAb (Cat. #AJ1702a).
  • WB - S100 beta Antibody (C-term) AJ1702a
    A. Western blot analysis on A375 cell lysate using anti- S100-beta RabMAb (Cat. #AJ1702a), dilution 1:1000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04271
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1576Y
Calculated MW 10713 Da
Gene ID 6285
Other Names Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human S100-? was used as an immunogen.
Dilution IHC~~1:250~500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsS100 beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name S100B
Function Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Cellular Location Cytoplasm. Nucleus
Tissue Location Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues
Research Areas
Citations (0)

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S100-? is a homodimeric member of the EF-hand calcium-binding protein superfamily. The protein has been implicated in cellular processes such as cell differentiation and growth, plays a role in cytoskeletal structure and function, and may have a role in neuropathological diseases, such as Alzheimers. The effects of S100-? are mediated via its interaction with target proteins (1). S100-? protein is a low molecular weight, EF-hand, Ca2(+)-binding protein widely distributed and conserved in the central nervous system of vertebrates (2). Measurements of Ca2+ binding to human brain S100-? (beta beta) protein revealed six Ca2+-binding sites and zinc-binding studies on human S100b protein showed that the protein bound two zinc ions per beta monomer. These results indicate that the Ca2+- and Zn2+-binding sites on S100-? protein are different and suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium (3).


1. Smith SP, et al. Structure 6(2):211-22, 1998
2. Allore RJ, et al. J Biol Chem 265(26):15537-43, 1990
3. Baudier J, et al. Biochim Biophys Acta 790(2):164-73 1984

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Cat# AJ1702a
(40 western blots)
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