|Application ||WB, IHC|
|Calculated MW||14747 Da|
|Other Names||Serum amyloid A-4 protein, Constitutively expressed serum amyloid A protein, C-SAA, SAA4, CSAA|
|Target/Specificity||A synthetic peptide corresponding to residues in human SAA4 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major acute phase reactant. Apolipoprotein of the HDL complex.|
|Tissue Location||Expressed by the liver; secreted in plasma.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Serum amyloid A (SAA) proteins are family of apolipoproteins of high density lipoprotein (HDL). They can be separated into two distinct groups. First group (SAA1, SAA2, and SAA3) consists of acute phase reactant whose expression level increase in the blood in a response to trauma, infection, inflammation, and neoplasia. These acute phase SAAs associates with HDL during inflammation and remodel the HDL particle by displacing Apo-A1. The second distinct group consists of SAA4 and SAA5 which exist as the minor apolipoproteins on HDL, but this group of SAA constitutes more than 90% of all the SAA during homeostasis, and it is thought to play a role in the normal functioning of the HDL particle (1, 2). The distribution of SAA4 is restricted to two lipoprotein subclasses; therefore, SAA4 has been suggested be a factor in lipid transfer between lipoprotein classes. SAA4 mRNA and protein expression in macrophage-derived foam cells of coronary and carotid arteries suggested a specific role of SAA4 during inflammation including atherosclerosis (3).
1. O Gutfeld et al., JHC 54 (1): 63-73, 2006. 2. MC de Beer et al., J Lipid Res. 36:526-534, 1995. 3. A Hrzenjak et al., Protein Engineering 14(12):949-952, 2001.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.