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SAA4 Antibody

Rabbit Monoclonal Antibody

Produced using Abcam's RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487
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United States
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Ordering Information
Catalog # SizeAvailability Price  
AJ1703a 100µl 2-3 days
$ 295.00email & fax$ 280.25online
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SAA4 Antibody - Product info

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary AccessionP35542
ReactivityHuman
Clone NamesEPR2926
Calculated MW14747 Da
Gene ID 6291
Target/Specificity
A synthetic peptide corresponding to residues in human SAA4 was used as an immunogen.
Dilution
WB~~1:10000~20000
IHC~~1:50
Format
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
SAA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

SAA4 Antibody - Protein Information

Name SAA4
Synonyms CSAA
Function
Major acute phase reactant. Apolipoprotein of the HDL complex.
Cellular Location
Secreted.
Tissue Location
Expressed by the liver; secreted in plasma.

SAA4 Antibody - Related products

AP17058b: SAA4 Antibody (C-term)

BP17058b: SAA4 Antibody (C-term) Blocking Peptide

SAA4 Antibody - Research Areas

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Serum amyloid A (SAA) proteins are family of apolipoproteins of high density lipoprotein (HDL). They can be separated into two distinct groups. First group (SAA1, SAA2, and SAA3) consists of acute phase reactant whose expression level increase in the blood in a response to trauma, infection, inflammation, and neoplasia. These acute phase SAAs associates with HDL during inflammation and remodel the HDL particle by displacing Apo-A1. The second distinct group consists of SAA4 and SAA5 which exist as the minor apolipoproteins on HDL, but this group of SAA constitutes more than 90% of all the SAA during homeostasis, and it is thought to play a role in the normal functioning of the HDL particle (1, 2). The distribution of SAA4 is restricted to two lipoprotein subclasses; therefore, SAA4 has been suggested be a factor in lipid transfer between lipoprotein classes. SAA4 mRNA and protein expression in macrophage-derived foam cells of coronary and carotid arteries suggested a specific role of SAA4 during inflammation including atherosclerosis (3).

REFERENCES

1. O Gutfeld et al., JHC 54 (1): 63-73, 2006. 2. MC de Beer et al., J Lipid Res. 36:526-534, 1995. 3. A Hrzenjak et al., Protein Engineering 14(12):949-952, 2001.